Surfactant protein-A2, annexin-3, calcium and integrin binding protein-1, leukocyte elastase inhibitor, chloride intracellular channel protein 1 and calcyphosine were all differentially expressed in infants with severe BPD born at 23–25 weeks gestation as compared to babies born at the same gestation age who did not develop BPD [103]. The gene discussed is CLIC1; the disease is bronchopulmonary dysplasia.