TFRC and Cerebral ischemia: Administration of drug therapy can alleviate cerebral ischemia injury, and its mechanism includes inhibition of ferroptosis through the transferrin receptor 1/divalent metal transporter 1(TFR1/DMT1) and solute carrier family 7 member 11/glutathione peroxidase 4(SCL7A11/GPX4) pathways [210].