It has been confirmed that Nrf2 expression increases after cerebral ischemia and reperfusion (I/R), which induces the production of many endogenous antioxidant enzymes, such as NQO1, HO-1, SOD, GST, GSH-Px, etc., thus reducing or eliminating oxygen free radicals and improving the antioxidant capacity of cells and tissues [156]. Here, HMOX1 is linked to brain ischemia.