Nrf2 mainly has seven highly conserved epichlorohydrin-related protein homologous domains (Nrf2 epichlorohydrin homology, Neh) [10,35] (Figure 1): The Neh1 region is a leucine zipper motif associated with intranuclear small musculoaponeurotic fibrosarcoma (sMaf), forms a heterodimer, recognizes and binds related sequences on the ARE, and can also interact with E2 ubiquitin-binding enzyme to adjust Nrf2 stability. This evidence concerns the gene NFE2L2 and fibrosarcoma.