GJA1 and colorectal carcinoma: In a cohort of 29 human microdissected samples of benign adenomatous polyps to poorly differentiated CRC, only Cx43 was found to be mutated in the multifunctional C-terminal domain of the protein, and its expression was restricted to invasive structures of exophytic CRC (50%) while absent in CRA and endophytic CRC, thereby demonstrating a potential role of the mutated Cx43 protein in the advanced stages of colon carcinogenesis [38].