Other computer-aided modelling approaches described the binding between Indicaxanthin and (i) the DNA methyl transferase 1 (DNMT1) [46], an enzyme involved in regulating epigenetic modifications; (ii) the N-methyl-D-aspartate receptor (NMDAR) [36], the most represented of the glutamate receptor family in hippocampus; (iii) the active form of IKKβ [79], the enzyme that controls the activity of the NF-κB inhibitor in physiological processes, as well as in inflammation-related disease and cancer [80]. This evidence concerns the gene NFKB1 and cancer.