AKR1B1 and ovarian carcinoma: In the ovarian cancer cell group, NS cell lines (A2780 and SKOV3 cells) revealed an AKR1B1 protein higher than the high-grade serous ovarian cancer cell lines (OVCAR3 cells), and SKOV3 cells showed the highest AKR1B1 level (Figure 1A,B and Figure S1).