This is in agreement with other studies highlighting the potential anti-oxidant effects of citrulline: an increase in SOD activity and a decrease in lipid peroxidation in the heart tissue in a rat model of sepsis [66]; a blunt in H2O2− induced ROS production in retinal epithelial cells while limiting lipid peroxidation and preventing cell death [67]; a renal decrease in oxidative-DNA damage without affecting the eNOS expression in spontaneously hypertensive rats [35]. This evidence concerns the gene SOD1 and Sepsis.