TXN and Sepsis: Among the positive effects of overexpression, for PRDX5, researchers have shown decreased DNA damage in hamster cell cultures CHO-K1 exposed to H2O2 and tert-butylhydroperoxide (tBHP) [162] as well as for TRX1 in the mitochondria of transgenic mice Trx1-Tg in vivo in sepsis-induced myocardial dysfunction and sham surgery [216,217].