SOD3 and serum lipopolysaccharide activity: We know that transgenic mice that overexpress SOD3 have increased resistance to rib cage irradiation with 4-MV photons [208], to focal cerebral ischemia [209], to 12-O-tetradecanoylphorbol-13-acetate (TPA) exposure [210], and to lipopolysaccharide-induced endotoxemia [20].