The genes involved in EGFR tyrosine kinase inhibitor resistance, the Ras signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway and renal cell carcinoma are related to angiogenesis, which has also been confirmed as an important way to cope with hypoxia pressure [53,54,55]. The gene discussed is EGFR; the disease is hereditary clear cell renal cell carcinoma.