The interactions of CXCR4, HIF2A, and PPAR are documented in the literature data, proving that the HIF2A transcription regulation of CXCR4 is involved in macrophage migration and chemotaxis [66], as well as the PPAR-related downregulation of CXCR4 gene expression in cancer cells [67]. This evidence concerns the gene CXCR4 and cancer.