Numerous metabolic pathways (including retinoate biosynthesis, glycine, serotonin degradations, glucocorticoid receptor signaling, nicotine degradation, thyroid hormone metabolism, and the role of lipids), immune response pathways, and thyroid hormone metabolism were among the key upregulated pathways in our ovarian normal cohort compared to ovarian tumors (RIG1-like receptors in antiviral innate immunity, and the role of cytokines in mediating communication between immune cells). This evidence concerns the gene NR3C1 and ovarian neoplasm.