AD belongs to the group of neurodegenerative proteinopathies and is characterized by the extracellular accumulation of amyloid-β (Aβ), forming amyloid deposits within the brain parenchyma, and abnormally phosphorylated tau protein, leading to an intraneuronal formation of neurofibrillary tangles (NFTs) [3]. The gene discussed is MAPT; the disease is Alzheimer disease.