The expression levels of IL-18, IL-1β, and the NLRP3 inflammasome in the serum of the three groups of mice were detected at the same time, and the expression levels of IL-18, IL-1β, and the NLRP3 inflammasome in PCOS mice were significantly higher than those in the control group. The gene discussed is IL18; the disease is polycystic ovary syndrome.