At the same time, the detection of caspase-1 and GSDMD and their shear fragments of ovarian GC pyroptosis also indicated that the related proteins of ovarian GC pyroptosis in PCOS patients were significantly higher than those in the control group, and the expression levels of IL-18 and IL-1β in follicular fluid were also significantly higher than those in the control group. Here, IL18 is linked to polycystic ovary syndrome.