When we analyzed cardiac GATA2, which was previously shown to exist mainly in endothelial cells (and not in cardiomyocytes) in the heart, we found a strong downregulation of the GATA2 protein in cardiac specimens from patients undergoing implantation of a left ventricular assist device (LVAD, to support cardiac function in advanced heart failure) compared to healthy myocardium (Figure 1a,b, Table S1). This evidence concerns the gene GATA2 and advanced heart failure.