In another randomized, double-blind study, 42 patients with diabetic nephropathy with an increase in urinary-albumin-creatinine ratio (UACR) >30 mg/g were divided into two groups and received 800 mg of EGCG (four capsules of green tea polyphenols; GTP) and placebo treatment, respectively, for 12 weeks. This evidence concerns the gene ALB and diabetic kidney disease.