IL10 and obesity due to melanocortin 4 receptor deficiency: The impact of IL-10 deficiency on obesity-related renal failure has also been reported previously, where a 12-week high-fat diet caused the IL-10 KO mice to develop severe lipid accumulation in the kidneys, elevated cholesterol, and increased expression of proinflammatory cytokines and chemokines compared to the low-fat diet fed IL-10 KO mice.