However, pretreatment with luteolin reduces the expression levels of these markers significantly by mitigating the activation of NF-κB and suppressing the release of TNF-α from immune cells and its infiltration into inflammatory cells, causing a significant reduction in interleukin levels and adhesion molecules, reflecting a protective role on the kidneys from LPS-induced AKI [108]. The gene discussed is TNF; the disease is acute kidney injury.