ANXA1 and chronic obstructive pulmonary disease: In COPD patients, our results show a significant positive correlation between serum sRAGE level and FEV1 predicted (r = 686, p < 0.001), a significant negative correlation between serum annexin A1 level and FEV1 predicted (r = −0.427, p = 0.001) and a significant negative correlation between serum sRAGE level and serum annexin A1 level (r = −0.263, p = 0.042), as shown in Figure 3.