As regards annexin A1, the results suggested a cut-off value of 10.7 ng/mL and AUC of 0.868 (91.67% sensitive and 82.50% specific, PPV = 88.7%, NPV = 86.8%, p < 0.001) between the COPD patient group and the control group. This evidence concerns the gene ANXA1 and chronic obstructive pulmonary disease.