In a study with mouse hepatocytes, out of three phytosterols tested (stigmasterol, campesterol, and sitosterol), stigmasterol proved to have the greatest potential in promoting cholestasis through antagonism of multipurpose fanesoid X receptor (FXR) function and reduction in expression of the canalicular bile acid transporter (ABCB11) [26]. Here, NR1H4 is linked to cholestasis.