CYP19A1 and Cognitive impairment: Indeed, our group showed that both the intact male and female, and ovariectomized GFAP-ARO-KO mice, which have E2 and aromatase depletion in astrocytes, lacked the normal elevation of aromatase and E2 in hippocampal astrocytes following GCI, and had increased ischemia-induced neuronal damage and cognitive deficits after GCI [19].