Interestingly, in other diseases characterized by pathological protein deposition, including Alzheimer’s disease and Parkinson’s disease, Nabs targeting amyloid-beta (Nabs-Aβ) and alpha-synuclein (Nabs-α-Syn), respectively, are currently considered important in the pathogenesis of these diseases [32,33,34] and, even if their role is far from being fully clarified, Nabs are generally considered protective against neurodegeneration [34,35]. This evidence concerns the gene SNCA and early-onset autosomal dominant Alzheimer disease.