Meanwhile, exosome-mediated M2 polarization could elevate the secretion of anti-inflammatory cytokines, including interleukin-4 (IL-4), interleukin-10 (IL-10), interleukin-5 (IL-5), transforming growth factor-β(TGF-β), and neurotrophic factors, which are beneficial to the recovery of brain function and the improvement of the prognosis of strokes [79,80,81]. This evidence concerns the gene IL4 and stroke disorder.