This pattern of CaMKII dysregulation has for instance been shown by Matsumoto and colleagues in the ischemic cortex following 1 and 2 h of ischemia as well as following 2 h of reperfusion in a mouse model of focal ischemic stroke (transient middle cerebral artery occlusion, tMCAO) [95]. This evidence concerns the gene CAMK2G and ischemia.