PTCH1 and neoplasm: However, when considering only prospectively collected data and multivariable tests, FANCC (LRR, HR = 6.6, CI [2.99–19.05], p = 0.0002), circulating tumor cells (CTC) (DFS, HR 4.3, CI [1.7–10.9], p = 0.002) and PTCH1 (LRR, HR = 5.98, CI [2.37–15.07], p = 0.0001) showed the strongest associations.