The oncolytic adenovirus expressing tumour metastasis suppressor protein (KISS-1) not only enhances the toxicity of the virus to tumour cells, but also inhibits the brain metastasis of tumour in the mice models of breast cancer by inhibiting the activity of VEGF and MMP-14 required for angiogenesis, thereby inhibiting the distant metastasis of tumour cells [94]; (4) apoptin is a tumour-specific pro-apoptotic protein which plays a vital anti-tumoral role in a variety of cancers, including melanoma, lymphoma, colon carcinoma, and lung cancer [95,96,97,98]. Here, VEGFA is linked to neoplasm.