The truncating variant in the RAD50 gene c.3271G>T (p.Glu1091*), reported also in Clinvar as pathogenic, was identified in patient p3 of the pCR group, i.e., in a patient who underwent complete tumor regression (TRG0); the same patient harbored the intronic variant c.3171 + 7G>T in the ATR gene, which is not described in the literature and is classified as VUS in Varsome. Here, RAD50 is linked to neoplasm.