Effectively, a hallmark of PD is the presence of aggregated α-synuclein, ubiquitin, neurofilaments, and molecular chaperones, present as an intraneuronal inclusions called Lewy Bodies (LBs), showing that aberrant protein homeostasis results in toxic accumulation of intracellular proteins, leading to neuronal loss [70,71]. The gene discussed is SNCA; the disease is Parkinson disease.