In the 40 subjects and the 53 pretreatment samples of HNSCC patients, the serum and saliva concentrations of TIMP-1 revealed a weak positive correlation (rho = 0.3, p = 0.004), while no significant correlation was seen for Hsp70 in the serum and saliva (Table 2). The gene discussed is TIMP1; the disease is head and neck squamous cell carcinoma.