This might include the counteraction of various arrhythmias [66,67,68,69,70,71,72,73,74,75,76,77,78,80,81,82,102,103,105,106,122,123,154] and thromboses, even blood pressure disturbances (intracranial (superior sagittal sinus), portal and caval hypertension, and aortal hypotension [66,71,72,73,74,75,76,77,78,79,80,81,82], or hypertension (hyperkalemia, NOS-blockade) [67,105] that were attenuated/eliminated peripherally and centrally)). The gene discussed is NOS1; the disease is hypertensive disorder.