Indicatively, BPC 157 induced a NO-release of its own [49,67,68] and therefore counteracted both NO-synthase (NOS) inhibition (i.e., N(G) nitro-L-arginine methylester (L-NAME) hypertension and pro-thrombotic effects) and NO overstimulation (L-arginine hypotension and anti-thrombotic, pro-bleeding effects) [49,67,69]. The gene discussed is NOS2; the disease is hypertensive disorder.