A recombinant fusion protein with the extracellular portion of membrane-bound gp130 linked to the Fc region of human IgG1 (sgp130Fc) was developed, and shown to block IL-6 trans-signaling effectively without inhibiting classical IL-6 signaling via membrane-bound gp130 [77] and strongly inhibit colon cancer growth [73]. Here, IL6ST is linked to malignant colon neoplasm.