The etiology of CTS and DD is believed to be associated with changes of blood vessel walls and sweat glands, as well as numerous profibrotic factors, including fibroblast and connective tissue growth factors (FGF, CTGF), transforming growth factors (TGF-β) and transmembrane proteoglycans [17,18]. The gene discussed is TGFB1; the disease is dentin dysplasia.