In the group of all malignant lesions, high CD8+ and GrB+ lymphocyte counts associated with poor recurrence-free survival (RFS) in a univariate survival analysis (p-values < 0.001 and 0.002, respectively); however, the result was not retained in a multivariate analysis, which took tumor stage as a covariate. The gene discussed is GZMB; the disease is neoplasm.