The authors also have reviewed the PSMA action in recycling and uptake of folate in the growing prostate cancer cells; and its indirect involvement in protein kinase B (AKT) pathway activation and cancer aggressiveness as well as the correlation of PSMA levels with downstream effects of mammalian target of rapamycin (mTOR) pathway directed anabolic events [139]. This evidence concerns the gene FOLH1 and Familial prostate cancer.