It will be of importance to evaluate correlations between the PSA level, PHI, mpMRI PI-RADS score of the prostate, and the disease severity with the levels of Zn in the prostate tissue as well as in biological matrices such as plasma, serum, seminal plasma, hair, and urine to understand whether Zn levels can enhance current prostate cancer predictions. Here, KLK3 is linked to prostate cancer.