ZFC3H1 and prostate adenocarcinoma: Using a bioinformatics approach on The Cancer Genome Atlas Database, Huang et al., 2021 report that the ZFC3H1 domain-containing protein expression is lower in prostate adenocarcinoma compared to adjacent non-cancerous tissue, although men recording higher expression levels were associated with lower survival [123] indicating a ‘U’ shaped cancer outcomes with ZFC3H1 levels.