Multiple studies record low prostate tissue Zn content in association with prostate cancer progression and severity, impairment of maintaining healthy prostate; interaction of Zn with insulin-like growth factor 1 (IGF-1), and its binding protein IGFBP-3; and association with total PSA level as reviewed by Li et al., 2020 [54]. The gene discussed is IGFBP3; the disease is Familial prostate cancer.