A systematic review of MMP genetic polymorphisms suggests that MMP3 11715A/6A and MMP9 rs17576 were associated with prostate cancer risk, while their meta-analysis shows no associations between MMP1 rs1799750, MMP2 rs243865, or MMP7 rs11568818 and overall prostate cancer risk [150]. Here, MMP1 is linked to Familial prostate cancer.