A transgenic adenocarcinoma of the mouse prostate (TRAMP) model with a Znt7-null genetic mutation has led to higher frequencies of low-grade prostatic intraepithelial neoplasia (PIN) and high-grade PIN at 6–8 weeks, higher frequencies of prostate tumors and their metastasis at 16 weeks, and worsening of prostate tumor frequencies at 28 weeks compared to the TRAMP mice [99]. The gene discussed is SLC30A7; the disease is prostate intraepithelial neoplasia.