Level of serum Zn may be useful alongside other factors such as genetics, demographic and lifestyle, comorbidities, family history of cancer, previous biopsy details, and interacting trace element profiles for developing algorithms to improve the efficiency of current prostate cancer screening marker PSA or more effective methods such as PHI, and mpMRI PI-RADS score [54,205,208,209]. This evidence concerns the gene KLK3 and prostate cancer.