IO combination therapy has been introduced and practice changing in first-line therapy of HCC in BCLC stage C. The combination of atezolizumab (PD-L1-inhibitor) and bevacizumab (VEGF-inhibitor) showed encouraging antitumor activity and safety in a phase 1b trial involving patients with unresectable hepatocellular carcinoma [238]. Here, VEGFA is linked to hepatocellular carcinoma.