To assess the possible clinical implications of R-PTP-κ by evaluating its relationship with E2F activity in patient tumor tissues, we analyzed the expression patterns of R-PTP-κ and known E2F1 target genes in public datasets generated from kidney renal clear cell carcinoma (KIRC, n = 534), colon and rectal adenocarcinoma (COAD, n = 469), cervical cell carcinoma (KIRC, n = 534), colon and rectal adenocarcinoma (COAD, n = 469), cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC, n = 304), and liver hepatocellular carcinoma (LIHC, n = 370). This evidence concerns the gene E2F1 and neoplasm.