Since psoriasis- and PRP-causing CARD14 mutations have been shown to result in a gain-of-function [4,18] and increased expression of CARD14 in the skin [4,15], we reasoned that overexpression of CARD14 in zebrafish may result in a phenotype relevant to human diseases which may subsequently be of help in ascertaining the effect of potential treatments on CARD14-induced cell signaling. The gene discussed is CARD14; the disease is psoriasis.