Not only were the morphological changes in the developing zebrafish skin reminiscent of the papulosquamous phenotype of psoriasis, gene expression was also consistent with the abnormalities seen in humans with gain-of-function mutations in CARD14, as CARD14 overexpression was clearly associated with up-regulation of the NF-kB pathway in zebrafish as previously seen in humans [4,17]. This evidence concerns the gene CARD14 and psoriasis.