As shown in Figure 8, serum MMP-9 showed significantly decreased activity in early PBC (4.31 ± 1.67 ng/mL, p = 0.05) as well as in late PBC (3.34 ± 1.36 ng/mL, p = 0.0001) compared to normals (5.65 ± 1.48 ng/mL). Here, MMP9 is linked to primary biliary cholangitis.