MMP1 and primary biliary cholangitis: As shown in Figure 6, serum MMP-1 showed significantly decreased activity only in late PBC (62 ± 17 ng/mL, p = 0.05) and not in early PBC (114.17 ± 59.64 ng/mL) compared to normals (121.79 ± 57.9 ng/mL).