MMP2 and primary biliary cholangitis: As shown in Figure 7, serum MMP-2 showed significantly decreased activity in early PBC (300.22 ± 78.01 ng/mL, p < 0.0001) as well as in late PBC (294.26 ± 60.62 ng/mL, p < 0.0001) compared to normals (426.47 ± 44.93 ng/mL).