TIMP1 and neoplasm: In multivariate surroundings only two predictor variables were significant for belonging to the invasive tumor group: increased TIMP-1 expression in the adjacent tissue with odds ratio (OR) of 3.97 (95% confidence interval (CI): 1.42–11.13; p = 0.009) and larger tumor size with OR of 1.81 (95% CI: 1.01–3.25; p = 0.048) (Table 3).