Up-regulated MMP-1 was found to be positively related to aggressive clinical features, worse survival, extracellular matrix-related pathways, oncogenic immune microenvironment, mutations, stemness, and dedifferentiation in PTC in a recent study reported by Zhou et al. using transcriptome data analysis of poorly differentiated cancer/anaplastic cancer and PTC from the Gene Expression Omnibus and the Cancer Genome Atlas databases [19]. The gene discussed is MMP1; the disease is anaplastic cancer.