TIMP1 and cancer: Numerous studies have reported that MMP-1, MMP-2, and MMP-9 enzymes and TIMP-1 and TIMP-2 inhibitors play an active role in angiogenesis, local invasiveness, and metastatic potential of malignant tumors [12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39].