In our study we report an increased TIMP-1 expression in tumor cells (95.0% (85.0–95.0%) vs. 82.5% (50.0–90.0%); p < 0.001) and significantly increased expression of TIMP-1 in the adjacent non-tumorous-tissue cells (80.0% (67.5–90.0%) vs. 50.0% (23.8–70.0%); p < 0.001) in invasive PTC when compared with non-invasive PTC. This evidence concerns the gene TIMP1 and neoplasm.