Among the genes containing the top CpG sites shown in Table 1 are the genes ADAMTS2, ADAMTS5, ADARB2, ADCY1, ADHFE1, AGRN, AKR1B1, ANK1, ANKRD13B, ANXA2, AQP5, ATP11A, BCAT1, BEND5, BOLL, CADM2 and CASR, which have been implicated in CRC [36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52]. Here, AKR1B1 is linked to colorectal carcinoma.