SMAD3 and colorectal carcinoma: Figure 4 shows the results of survival analysis for the 13 CpG sites that were predictive of survival along with probe IDs. In the figure, the names of the genes the CpG sites map to are included in the Figure legend. To determine whether any of the discovered genes containing CpG sites predictive of survival have been implicated in CRC, we performed in silico validation using published literature. In silico validation revealed the genes CDH12, NR5A2, DCLK1, NKX2-2, ADARB2, MAGI2, SMAD3, GUCY1B3 and EFS (Figure 4), which have been implicated in CRC [38,52,53,54,55].