Given that TILs are often compromised for anti-tumor effector functions due to upregulation of the immune checkpoint proteins PD-ligand (L)1, V domain-containing Ig suppressor of T-cell activation (VISTA), TIM-3 and CTLA-4, it is important to elucidate whether immune checkpoint inhibitors (ICHs) also reinvigorate the anti-tumor function(s) of MAIT cells in addition to conventional T cells and NK cells. The gene discussed is VSIR; the disease is neoplasm.