On the one hand, a group of lines including Cdkl5−/y, Il1rapl1−/y, Ptchd1−/y, Atp6ap2Camk2a/y, Mbd5+/−, and Ehmt1+/− displayed alterations mainly in activity, repetitive behaviour, novelty exploration and anxiety (Axis 1). This evidence concerns the gene PTCHD1 and Anxiety.