MED25 and congenital cataract-microcephaly-nevus flammeus simplex-severe intellectual disability syndrome: Our results from Med25−/− embryos revealed several abnormalities including exencephaly, anophthalmia or cyclopia and telencephalon hypoplasia, in line with those observed in humans with MED25 mutations such as Basel-Vanagaite-Smirin-Yosef syndrome characterized by severely delayed psychomotor development resulting in ID, as well as variable eye, brain, cardiac, and palatal abnormalities [47].