In a study in patients with diabetic foot ulcers who significantly improved following HBO, Dhamodharan et al. found Nrf2 along with its downstream targets NAD(P) H:quinone oxidoreductase 1 (NQO-1), Heme-oxygenase-1 (HO-1) and Catalase (CAT) significantly increased when compared to controls. Here, HMOX1 is linked to diabetic foot.