GLA and Nager acrofacial dysostosis: Anderson–Fabry Disease (AFD) is an inherited sphingolipidosis due to a deficit of the lysosomal enzyme alpha-galactosidase (a-GAL A), which is responsible of the hydrolysis of terminal, non-reducing α-D-galactose residues in α-D-galactosides, catalyzing many catabolic processes, including cleavage of glycoproteins, glycolipids, and polysaccharides.