The second suggests a cooperative function between RUNX2 and three transcription factors (BRCA1, FOXM1, and RUNX1) important for the specific regulation of lung cancer establishment and progression [12,31], along with three transcription factors (E2F3, FHL2, and TWIST1) of the NSCLC-GRN (Figure 1). This evidence concerns the gene E2F3 and lung carcinoma.