E2F3 and lung cancer: Furthermore, the transcriptional regulatory network of lung cancer built with the RTN library (Figure 3) allowed the identification of the total number of target genes of the transcriptional regulator RUNX2 and its six coregulators, E2F3, FHL2, TWIST1, BRCA1, FOXM1, and RUNX1, divided into the number of targets that each TF regulates positively and negatively (Table 3).