RUNX2 and lung disorder: Similarly, RUNX2 is also a coregulator of RUNX1 (Figure 2), a TF of the same family, and is coexpressed in coexpression networks of unique lung cancer DEGs that are not dysregulated in other lung diseases (LCI) [12] or in other types of cancer (LCII) [31], with which it shares binding motifs with its target genes (Figure 3).