Four hundred and thirty-two genes were identified as potential RUNX2 targets in the TRN analysis, of which one hundred and one are significantly related to cancer (pc value: 4,1E−2), twenty-two have been specifically associated with lung cancer, and nineteen (CD19, COL1A1, COL1A2, COL6A3, COMP, EFNA4, FGFR4, ITGA11, ITGAV, LAMA1, LAMC3, LPAR2, LPAR5, MAGI1, PDGFC, PPP2R5A, SPP1, THBS2, and TNC) are related to the PI3K-Akt signaling pathway. This evidence concerns the gene PPP2R5A and lung cancer.