GRN and lung cancer: The gene regulatory network (NSCLC-GRN) identified six regulators (Figure 1) for which there is evidence of their ability to form coregulatory complexes with each other and other transcription factors important for specific lung cancer establishment and progression (Figure 2), and probably with other cofactors [34,35,36], to fulfill their regulatory function as a repressor or activator of gene expression in lung cancer.