The association of ETS1 as a direct target of RUNX2 in lung cancer strengthens the evidence that RUNX2 is a critical transcriptional regulator since the coregulation analysis showed that ETS1 is a coregulator of a significant number of TFs identified in the networks of coexpression (Table 1) (Figure 2), among which are NR4A2 and ZEB1, two important transcription factors for the establishment and progression of the tumor process in the lung that appeared in several networks coexpressed with unique DEG hits for lung cancer [12]. This evidence concerns the gene RUNX2 and neoplasm.