DAVID Functional Annotation and Enrichment Analysis showed that fifty RUNX2 targets are statistically significantly associated with cancer (pc value: 1.3 × 10−4), of which nineteen are specifically associated with lung cancer (pc value: 1.5 × 10−4), and some are associated with signaling pathways such as TGF-beta (pc value: 1.3 × 10−10), Hippo (pc value: 1.3 × 10−6), Wnt (pc value: 3.0 × 10−3), Notch (pc value: 2.9 × 103), and the regulation of pluripotency in stem cells (pc value: 3.7 × 10−6). The gene discussed is RUNX2; the disease is lung cancer.