Moreover, RUNX2 is a coregulator of three of the transcriptional regulators identified in the NSCLC-GRN (i.e., E2F3, FHL2, and TWIST1) (Figure 2), suggesting a cooperative function of these TFs in lung cancer, which has not been studied experimentally in lung cancer. The gene discussed is E2F3; the disease is non-small cell lung carcinoma.