The Hippo signaling pathway inhibits the YAP and TAZ transcriptional coactivators by phosphorylation, while the TGF-beta signaling pathway positively regulates TAZ, which interacts with RUNX2 by coactivating it to promote cell differentiation in mesenchymal stem cells [64] and thus induces a tumor phenotype [65], while YAP can act as an inhibitor of RUNX2 [66]. The gene discussed is RUNX2; the disease is neoplasm.