CD97/ADGRE5 is highly elevated in breast, thyroid, stomach, pancreatic, esophageal, and colorectal cancers, and has been linked to tumor metastasis through the β-catenin, PI3K/AKT, MAPK, and Rho-GEFE signaling pathways [37,38,39,40,41,42]. This evidence concerns the gene ADGRE5 and colorectal cancer.