On the contrary, when M2 macrophage polarization inhibitors (O-ATP, trametinib, and bardoxolone methyl) were added to the co-culture system, there was a significant decrease in CD163, IL-6, and IL-10 mRNA levels in the myeloid portion, along with a decrease in EMR1 expression in both cancer and myeloid portions (Figure 5A–G). This evidence concerns the gene ADGRE1 and cancer.