A subsequent study performed in Epm2a−/− and Epm2b−/− mice confirmed that PBs colocalize in neurons, astrocytes, and microglial cells [40] and that the formation of astrocytic PBs precedes that of neuronal PBs, as is the case of other glycogen storage diseases [69]. Here, EPM2A is linked to Glycogen storage disease due to glycogenin deficiency.