Rigorous cell culture experiments combined with RNAseq analysis demonstrated the ability of primary PDAC tumor cell culture supernatants from the DNA methylation-low, RE-activated, IFN sign ‘high’ phenotype pancreatic tumor cells (MC2 type) to reprogram normal pancreatic stromal fibroblasts to a more proinflammatory and tumor-promoting phenotype. This evidence concerns the gene IFNA1 and neoplasm.