RNF2 and cancer: Other factors, such as the embryonic transcription factor double homeobox 4 (DUX4), lymphocyte adapter protein (LNK), the ubiquitin ligases RING finger protein 2 (RNF2), and the protein kinase D2 (PKD2) have been implicated in impaired IFN and MHC-I signaling in different cancers [14].