Although the different complications in sepsis result from a deregulated pro-inflammatory response, after two hours of the sepsis onset an immunosuppressive phenomenon begins to be triggered [28] due to the depletion of CD4 and CD8 lymphocytes because of their splenic sequestration and also apoptosis of CD4 lymphocytes induced by the large number of cytokines in the early stage of sepsis development [28]. This evidence concerns the gene CD8A and Sepsis.