In a cross-sectional study by Brown et al., an adjusted prevalence of biochemically overt PA diagnosed by oral salt loading (with a threshold of 10 ug/d) among patients with suppressed PRA was 19.9% in normotensives (n = 239), and 27.4% in untreated patients with stage 1 HT (n = 89) [2]. This evidence concerns the gene S100A6 and hematocrit.