JAK2 and COVID-19: The preliminary results highlighted a higher prevalence of AAbs to IFN-I in patients with MPN compared to the general population, an association with the JAK2-unmutated genotype, with ET diagnosis, and a potential higher rate of severe COVID-19, suggesting that AAb detection may enable early identification of patients who are likely to develop life-threatening COVID-19 in a vulnerable population, such as patients with HM.