Traxler et al., [53] found that increased production of pyruvate kinase (PKM) 2 (an essential glycolytic enzyme, which catalyses the conversion of phosphoenolpyruvate to pyruvate) as opposed to PKM1 in patient-derived induced neurons may be responsible for initiating this switch, correlating with an increase in the PKM2 to PKM1 ratio in the prefrontal cortex of AD patients. This evidence concerns the gene PKM and Alzheimer disease.