Recent data in mice show that myocardial infarction (MI) produces remote global endothelium activation, with up-regulation of the vascular cell adhesion molecule (VCAM-1), the cell adhesion molecule (P-Selectin) and platelet adhesion in remote arterial and microvascular beds, which persists for longer periods in animals with preexisting atherosclerosis [64,65]. Here, VCAM1 is linked to myocardial infarction.